Tonight’s (April 30th) Salt Lake City / Sandy Engage Global Opportunity Meeting has been canceled.

The regularly scheduled Thursday Night meeting will be canceled tonight in SLC / Sandy due to an Engage Global Leadership Summit running throughout the day in Provo.

We are sorry for the inconvenience this may cause for any of you planning to attend this meeting tonight.

Please make note:  The May 7th meeting is also canceled due to over booking at the hotel, these issues are beyond our control.

We will be combining our meetings on may 6th at the corporate offices in Provo.

Normal meetings in SLC will resume again May 14th.

for Question or concerns or scheduling concerning the SLC meetings please contact Gary Richins  gary@engage-global.com

MMF is proven to combat Oxidative stress! Oxidative Stress In Disease

MMF is proven to combat Oxidative stress!

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By Dr Ananya Mandal, MD

Reactive oxygen species or ROS and free radicals can cause severe damage to the normal cells of the body. This damage can be to the DNA, proteins, and other macromolecules. This damage forms the basis of a wide variety of diseases, most notably heart disease and cancer.

There are numerous studies that prove that since these diseases are mediated by oxidative stress and disbalance between pro-oxidant and antioxidant factors, antioxidants may play a pivotal role in preventing or slowing the progression of these conditions.

Some of the notable diseases caused due to oxidative stress include:

Heart Disease
Heart disease is the leading cause of death worldwide. Heart disease risk is raised by several factors including high cholesterol levels, high blood pressure, cigarette smoking, and diabetes. These promote atherosclerosis. Atherosclerosis refers to formation of hardened walls of the arteries that impairs blood flow to the heart and other vital organs.

It is speculated that a critical step in development of atherosclerosis is oxidation of low-density lipoprotein (LDL) (a type of bad cholesterol in blood) within the arterial wall. Several studies show an association between low intakes of dietary antioxidants to an increased frequency of heart disease.

On the other hand, those with high blood levels of antioxidants have lower risk of heart disease. For examples, humans who took more vitamin E on a regular basis had a 41% lower incidence of heart disease than those who took less amounts as seen in a study on nurses. Dietary increases in antioxidant vitamins may reduce the risk of heart disease by 20-30%.(1)

Cancer
Cancer kills millions worldwide. Diet may be the cause for cancer in as much as 35% of all human cancers. Low antioxidant intake in diet may also be responsible. Low dietary intake of fruits and vegetables doubles the risk of most types of cancers.

Pro-oxidants, or those who generate free radicals, stimulate cell division and these form the beginnings of mutagenesis and tumor formation. When a cell with a damaged DNA strand divides, it gives rise to disturbed and deformed clusters of cells that form the cancer.

Antioxidants exert their protective effect by:

decreasing oxidative damage to DNA and
decreasing abnormal increases in cell division
In addition, cigarette smoking and chronic inflammation lead to strong free radical generation that seems to be the reason for many cancers. Some research has indicated that people who smoke tend to have lower antioxidant levels than non-smokers and this makes smokers more at risk of cancers.

Lung diseases
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The respiratory system is a well known target for free radical insult. This comes from endogenous factors as well as exposure to air pollutants and toxins, cigarette smoke etc.

Recent studies suggest that free radicals may be involved in the development of pulmonary disorders such as asthma. Antioxidants have been seen to reduce the development of asthmatic symptoms. Vitamin C, vitamin E, and beta carotene supplementation has been associated with improved lung function.

Neural disorders
Free radicals can also damage nerves and the brain. Neural tissue may be particularly susceptible to oxidative damage. This is because the brain receives a disproportionately large percentage of oxygen and has large amounts of polyunsaturated fatty acids which are highly prone to oxidation and oxidative damage.

Diseases implicated to oxidative stress include:

Alzheimer’s disease
Parkinson’s disease
dementia etc.
Cataracts
Formation of cataracts is believed to involve damage to lens protein by free radicals. This leads to opacity of the lens. Cataract formation may be slowed with the regular consumption of supplemental antioxidants like vitamin E, vitamin C, and the carotenoids.

Other diseases
Other diseases like Diabetes, Rheumatoid arthritis etc. are also associated with low antioxidant levels in blood.

Tuesday’s 8:15 PM (MST) ( Weekly) MMF in Action! Training Call! Hosted By Freedom 1 Leader Dr. Milton Carroll

Tuesday’s 8:15 PM (MST) ( Weekly)

MMF in Action! Training Call!

Conference Dial-In Number: (605) 562-3140

Participant Access Code: Pin- 104583#

Play Back Number: (605) 562-3149

Participant Access Code: Pin- 104583#

 Hosted By Freedom 1 Leader Dr. Milton Carroll

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Optomizing Glutathione for Health and Human Performance

Optomizing Glutathione for Health and Human Performance

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Many of us, me included, have thought of ways to improve our health in this New Year. Perhaps you have kicked off a new fitness regime or have started a new diet plan. As we begin the journey to better health, I want to bring attention to a molecule called glutathione and its implications for health and human performance.

Glutathione is one of the most powerful antioxidants responsible for maintaining cellular health. It is found in all cells, but is highly concentrated in the brain and liver. Glutathione is a chief biomarker of cellular redox status (electron allocation), meaning it can accept electrons from free radical species. Less glutathione increases the cell’s vulnerability to oxidative damage, and consequently increases the risk for disease.1 It is good that our body naturally produces glutathione , however many have less than optimal glutathione levels due to stress, infection (HIV and Hepatitis C), poor diet, lack of sleep, and exposure to toxins and xenobiotics (statins, hormonal contraceptives, analgesics).

Deficiencies in glutathione leave the body vulnerable to toxins and inflammation—making the body weak and robbing one of high performance. Worst of all, low glutathione levels are linked to diseases including: autism1, atherosclerosis, coronary artery disease2, Alzheimer’s disease3, Crohn’s disease4, leukemia5, inflammatory bowel disease6, celiac disease7, osteoarthritis8 and chronic fatigue syndrome9.

Despite differing in biochemical pathways, these diseases are facilitated by high levels of oxidative stress. Oxidative stress is an imbalance between free radicals and antioxidant defenses and is a primary cause of cellular damage leading to disease.10 Throughout a life span, one is constantly exposed to free radicals through strenuous work, environmental toxin exposure, diet, and autoimmune disorder. Even something as essential as oxygen can be toxic under certain conditions, and this phenomenon is called the oxygen paradox.11

There is good news however. We can take an active role in preventing disease by increasing our antioxidant capacity. Antioxidants protect the cell from free radicals by accepting their unpaired electrons, thereby quenching the free radical’s reactivity. Reducing free radicals protects the cell from oxidative damage and, ultimately, facilitates disease prevention. A large body of literature supports the notion that dietary antioxidants play an important role in preventing many human diseases.11

Glutathione is called the “master antioxidant” by some and for good reason. As antioxidant, its primary functions include:

  • Scavenging free radicals and reactive oxygen species12
  • Removing hydrogen and lipid peroxides
  • Preventing oxidation of biomolecules
  • Removing the carcinogen formaldehyde from the body13
  • Reacting with electrophiles, free radical metabolites, and xenobiotics12
  • Reacting with mold toxins.14

Glutathione has many other responsibilities in addition to antioxidant function, including metabolism and cellular regulation, which will not be included here. For comprehensive reviews see sources 12 and 13.

By quenching free radicals, glutathione facilitates a decrease in oxidative stress at the cellular level. At the organismal levels, the effects are manifest as: increased energy, better sleep quality exercise recovery, and blood circulation15, mental clarity, less inflammation, and slower aging. Additionally, glutathione recycles other antioxidants and antioxidant enzymes including vitamin C, E, lipoic acid, CoQ10, super oxide dismutase, and catalase.11

So how do we optimize our glutathione levels?

The most obvious way to increase glutathione is through direct supplementation. However taking an oral supplement is ineffective, as it denatures in the stomach before it has pharmacological effects. Intravenous glutathione is an option, however I would consult your physician before taking further action. Another option for direct supplementation is liposomal glutathione, that is, glutathione encapsulated in tiny fat cells. I have no idea if this actually works, but I am willing to give it a try.

Other practical ways to optimize your glutathione levels include:

  • Taking a cold shower or ice bath16

A German study demonstrated increased glutathione levels and related biomarkers in the blood of swimmers who swam at least once per week in ice-cold water for 5-10 minutes. I plan on testing this in the future.

  • Eating undenatured whey protein

Glutathione is synthesized from its precursor amino acids cysteine, glutamic acid, and glycine and undenatured whey has these glutathione precursors. I supplement Proserum Grass-Fed Whey Protein Concentrate as it is the cleanest sourced protein I could find on the market. Also, I stir my protein into solution using warm water. I do not blend as doing so breaks-up the protein reducing its quality.

  • Supplementing amino acids: cysteine, glutamine (different from glutamate), glycine, and methionine

Cysteine is the limiting amino acid in glutathione synthesis, thus increasing its precursor stimulates cysteine uptake by the cells and increases intracellular glutathione production.12 N-acetylcysteine is a stable and effective source to supplement glutathione synthesis.11 I have started supplementing 200mg daily with lunch.

Although it is one of three building blocks for glutathione synthesis, glutamate is actually broken down in the small intestine, thus supplementing the amino acid is ineffective for those looking to increase their glutathione levels. However, the amino acid glutamine is hydrolyzed to glutamate by the enzyme glutaminase, and the ketone alapha-ketoglutarate produces glutamine from branched chain amino acids— readily supplying glutaminase ingredients to produce glutamate and, ultimately, glutathione.11

The amino acid glycine can be directly supplemented, and has been shown to increase glutathione concentration in the liver cells of protein-deficient mice.11

Methionine is another amino acid one can supplement, as it is not synthesized by the body and can only be supplied through diet. This amino acid reacts with the enzyme gamma-glutamylcysteine synthase in liver cells to produce cysteine.12

  • Supplementing alapha-lipoic acid

Doing so gives the body another way to produce cysteine for glutathione production, as this antioxidant reduces the amino acid cystine to cysteine.17 In the past I have taken 200mg supplements with lunch.

 

  • Selenium

Dietary selenium supports glutathione peroxidase which is an important enzyme for recycling glutathione.17A dietary deficiency of selenium has been shown to decrease tissue glutathione peroxidase activity by 90% leading to peroxidative damage and mitochondrial dysfunction.11 One can increase their selenium by simply supplementing 100mcg with a meal (I haven’t taken this supplement before so I cannot speak to its effects) or eat foods rich in selenium such as grass-fed beef and wild-caught oysters.

  • Magnesium

A deficiency in dietary magnesium reduces glutathione reductase, another enzyme responsible for recycling glutathione. Magnesium is a cofactor for two pentose-cycle enzymes that catalyze the production of Nicotinamide adenine dinucleotide phosphate (NADPH) and its oxidized form NADP+. 12 The oxidation NADPH gives a proton to glutathione reductase so it can help recycle glutathione. In short, magnesium facilitates the recycling of glutathione. Supplement 600 to 800mg per day of magnesium malate, citrate, or aspartate, but be careful as too much can lead to diarrhea. The best time to take magnesium is in the evening since it confers relaxing effects.

  • Eating sulfur rich foods

Mineral elements like sulfur are available to us exclusively through dietary protein, yet only 2 of the 20 amino acids normally present in protein contain sulfur, and these include cysteine and methionine. Proteins contain between 3 and 6% sulfur amino acids and as stated earlier, cysteine is the limiting amino acid in glutathione synthesis and methionine facilitates cysteine production, neither of which are stored in the body.18 Thus we can increase our glutathione supply by eating food rich with these proteins. These include grass-fed beef, pork, lamb, or chicken. Wild caught and low mercury sea food is another good choice— salmon, king crab, and shrimp to name a few. Other sources include: soft-boiled eggs (so the protein and fats don’t go rancid from overheating), onions, garlic, broccoli, and red pepper.

 Glutathione is one of the most powerful antioxidants that can improve our health and performance by helping our bodies run better, giving us more energy, decreasing inflammation from oxidative stress, and ultimately reducing our risk for disease.

MMF is proven to help the body increase its glutathione levels.
  MMF is the most powerful antioxidant supplement available.   Patented. Proven.
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Join us tomorrow night at Engage Global head quarters for our weekly Wednesday night opportunity meeting!

Provo, Utah

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What: Opportunity Meeting at EngageDNA, Inc. HQ:
Business Opportunity Presentation (bring all your guests!)
When: Wednesdays
Time: 7:00 pm
Venue: 
EngageDNA, Inc. Corporate Office
5314 North River Run Road
Provo, Utah
(801) 310-0673
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A Message From Engage Global….ONLY 2 DAYS LEFT! SPECIAL ANNOUNCEMENT!

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ONLY 2 DAYS LEFT!

SPECIAL ANNOUNCEMENT!

To celebrate the introduction of our “VeggieCap MMF” Engage is offering the following packs with a 10% discount through Thursday, April 30th to ALL members:

  • Fast Start Pack – SAVE $50 and instantly rank advance to Liberty 1!   (#33500, was $500, NOW ONLY $450!)
  • Fast Start Builder Pack – SAVE $100 and instantly rank advance to Liberty 2!   (#33600, was $1,000, NOW ONLY $900!)
  • Freedom Pack – SAVE $250 and instantly rank advance to Liberty 2!   (#33777, was $2,500, NOW ONLY $2,250!)

ALL MMF IS NOW SHIPPING in an all-natural, plant-based, chlorophyll capsule!

This special promotion ends at 5:00p.m. MT on Thursday, April 30th, so don’t delay!  Order your “VeggieCap MMF” TODAY at a fantastic price!

Sincerely,

Team Engage